|
KMID : 1161420100130061402
|
|
Journal of Medicinal Food
2010 Volume.13 No. 6 p.1402 ~ p.1408
|
|
|
In Vivo Antimutagenic Properties of Transgenic and Conventional Soybeans
|
|
Azevedo Luciana
Dragano Nathalia R. V.
Sabino Ana P. L.
Resck Maria Christina C.
de Lima Patricia L. Alves
Gouvea Cibele M. C. P.
|
|
|
Abstract
|
|
|
|
The goal of the this study was to evaluate the mutagenic/antimutagenic effects of conventional (BRS133) and transgenic (BRS 245 RR) soybeans (CS and TS, respectively) in vivo using the bone marrow micronucleus (MN) test, histopathological analysis, chromosome aberration test (CAT), and mitotic index (MI) determination. Six-week-old male Swiss mice were fed with pelleted commercial diet mixed with CS or TS at 10% or 20%. Two experimental designs (MN and CAT) were conducted simultaneously with 10 groups each during a 15-day period. Animals were treated with pelleted commercial diet, CS (10% or 20%), or TS (10% or 20%), and on day 14 they also received cyclophosphamide (CP) (50?mg/kg i.p.). The 10% and 20% CS and TS diets did not significantly decrease the frequencies of micronucleated polychromatic erythrocytes in bone marrow induced by CP. However, the CAT indicated that the 10% and 20% CS diets significantly (P?
|
|
|
KEYWORD
|
|
|
antimutagenicity, conventional soybean, cyclophosphamide, mice, mutagenicity, transgenic soybean
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|